Docking effect of Terminalia chebula active ingredients on immune system cell receptors and immune system-responsible receptors in bone marrow mesenchymal cells

Document Type : Research paper

Author

M.Sc., Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

Abstract

Bone marrow mesenchymal cells are responsible for the production of white blood cells, red blood cells, platelets, and plasma and play an important role in the body's immune system. Terminalia chebula has immune-boosting properties, and reports on the effects of Terminalia chebula on the immune system confirm these properties. In order to investigate the effects of Terminalia chebula on the immune system, the main active ingredients of Terminalia chebula were selected and their effects on immune cell receptors and receptors responsible for the immune system in bone marrow mesenchymal cells were evaluated using molecular docking software. Docking results showed that most of the active ingredients of this plant, such as chebulic acid, ethyl gallate, proline, etc., especially the most active ingredient of Terminalia chebula, chebulic acid, have much lower binding energy than non-specific ligands that were randomly selected, on the receptors of immune system cells and the receptors responsible for the immune system in bone marrow mesenchymal cells. To further investigate the two bone marrow receptors ER and PPARγ and their specific ligands Propanenitrile and Glitazone were compared with the ligand chebulic acid and its specific receptor VEGF. The results obtained from molecular docking interactions, such as lower binding energy and inhibition constant and morehydrogen bonds, can confirm the mechanism of the effect of Terminalia chebula on strengthening the immune system.

Keywords

References

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Advanced Research in Medicinal Plants
Volume 2, Issue 3 - Serial Number 4
November 2025
Pages 57-68

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History

  • Receive Date: 28 September 2025
  • Revise Date: 17 November 2025
  • Accept Date: 23 November 2025

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